Home » CBD And Gut Health: What’s The Connection?

CBD And Gut Health: What’s The Connection?

Robust gut health isn’t about digestion. Instead, it profoundly links to various physiological processes,including cell regeneration, defense against bacteria and viruses, toxin elimination, hormone regulation, and many more.

The GI tract controls numerous activities while the gut functions like the “second brain” in the digestive system. When disease, poor nutrition, pollutants, or stress affects the brain, the gut has a significant impact on how you operate. This is why a substance like cannabidiol (CBD), which has profound effects throughout the digestive system, has shown promising upshots for gut health. A variety of CBD oils are available at Eagle Moon to restore gut health.

Let’s understand the vital connection between your gut and CBD so that you enjoy the therapeutic potential of CBD and relish a healthy gut.

The Gut Feeling

Besides being a metaphor for instincts and bravery, the gut is the only defense mechanism against external threats. Since it comprises the entire intestinal system, the intestinal tract’s lining protects against pests or toxins from entering the bloodstream through the GI tract. That’s why it’s so important to keep your gut healthy. Some people use supplements like Total Restore (try looking for a Total Restore coupon code if you’re interested), but the food you eat also makes a difference. Essentially, taking care of your gut will ensure the smooth functioning of your overall health. 

Experts believe that your gut is the second most crucial part of your body after the brain and is often referred to as ‘the second brain.’ It has a direct link to your brain. Your gut produces about 90% of serotonin, the ‘feel-good’ neurotransmitter of your body. This tells your brain that your body is running smoothly without any hassles.

The Gut’s Endocannabinoid System

The central nervous system and the gut maintain constant communication to regulate neurotransmitter production and motility, protect your intestinal barrier, and many more functions. Keeping all these essential communication systems running efficiently depends on continuous interaction from your endocannabinoid system (ECS), which is the most extensive regulatory system in your body. The ECS relies on neurotransmitters’ production to interact with their corresponding endocannabinoid receptors and maintain a balance in the body.

There are two main cannabinoids (messengers of ECS) synthesized in your body (endocannabinoids) – anandamide and 2-Ag (2-arachidonoylglycerol). These two endocannabinoids regulate the communication between your gut and the brain. Ideally, the body produces endocannabinoids when needed, and the metabolic enzymes in the body break them down to control essential processes’ efficient functioning. But the impact of injury, stress, or illness may lead to more production of cannabinoids than the body can create. Due to this reason, endocannabinoid deficiencies may cause disease.

Fortunately, the cannabis plant provides cannabinoids, and your body is also geared to respond to these. Out of more than 113 phytocannabinoids found in cannabis, CBD mimics the effects of the endocannabinoids made in your body. It interacts with the receptors of the ECS to help support crucial functions, including those of your gut. 

The CBD And Gut Connection

CBD is an exogenous cannabinoid or phytocannabinoid, whereas endocannabinoids are produced internally. CBDcan influence the ECS and its array of interconnected systems. Considering the interaction with the ECS, CBD could help to promote proper gut health. Here are some of its possible effects that will give an insight into the connection between the gut and CBD.

1. Promoting Overall Digestive Health 

CBD can help with many different aspects of digestion. It stimulates the cannabinoid receptor (CB1) in the body, coordinating the gut motility. The receptor interaction can slow down the stomach’s emptying, reduce stomach acid, and improve nutrient absorption. A study found that CBD can help with different types of gut discomfort, including nausea and vomiting. By cannabinoid stimulating receptors, CBD can significantly increase appetite.

2. Modulating Inflammation

CBD is a potent immune system regulator. It stimulates CB1 and CB2 receptors to reduce inflammation within the digestive tract. This stimulation has a calming effect within the brain, linked to improved nutrient absorption and assimilation. Moreover, CBD can reduce intestinal inflammation by inhibiting proinflammatory cytokine production.

3. Promoting the Growth of Good Bacteria

CBD interacts with the endocannabinoid system to create a proper balance within the bodily systems. This helps support gut flora and pH to provide a suitable environment for good bacteria. Good bacteria support the gut barrier, while the harmful bacteria can result in leakage and a weak intestinal wall. CBD promotes the growth of good bacteria in your gut to improve your digestive system’s overall health.

4. Restoring a Healthy Intestinal Barrier Function

The disruption of the delicate balance of gut microbiota gives rise to harmful bacteria in the gut. The imbalance can trigger inflammation that increases intestinal permeability. This allows harmful bacteria to pass through the intestine and migrate to other parts of the body. The condition is termed Leaky Gut Syndrome. Fortunately, CBD provides relief from this condition’s symptoms, including chronic diarrhea or constipation, inflammation, fatigue, skin issues, and joint problems. CBD can help restore the healthy intestinal barrier functions by promoting helpful bacteria’s growth and reducing harmful ones’ permeability.


CBD and gut health share an intimate connection. Through its direct effects on the ECS, CBD not only supports your gut integrity but also boosts homeostasis and prevents gut disorders. Making CBD a part of your supplement program can promote your gut health and functionality. One can also combine vitamins and CBD products to delay the gastrointestinal and neurodegenerative diseases’ onset in the gut microbiome.